1-Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazine → 1-[3-(1,1-Dimethylethylamino)pyridyl]piperazine
反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([NH:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH3:24][C:21]([NH:20][C:19]1[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:15][CH:16]=[CH:17][CH:18]=1)([CH3:22])[CH3:23]参加物
5
実験手順
1- Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazine (PREPARATION 96, 4.25 g, 13.10 mmol) is dissolved in 100 ml ethanol. Palladium (10% on carbon, 1.0 g) is added and the solution hydrogenated at 40 psi hydrogen gas. The mixture is filtered and concentrated to give the title compound, NMR (300 MHz, CD3OD) 7.53, 7.19, 6.93, 2.95, 1.39 δ.
後処理
- filtrationThe mixture is filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-f87236048290426e8144f2d1fdb4d147
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05599930
反応ノート
読み込み中…