Water → Ibuprofen, Sodium Salt

HRID 1449781

反応式

HRID 1449781 の反応式
[OH:1][C:2]([CH:4]([C:6]1[CH:15]=[CH:14][C:9]([CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:8][CH:7]=1)[CH3:5])=[O:3].O.[OH-].[Na+:18]>C1(C)C=CC=CC=1>[Na+:18].[O-:3][C:2]([CH:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][CH:11]([CH3:12])[CH3:13])=[CH:14][CH:15]=1)[CH3:5])=[O:1]

参加物

5

反応物 3

HCID 962WaterHCID 3672Ibuprofen, (+-)-HCID 14798Sodium Hydroxide

生成物 1

HCID 5338317Ibuprofen, Sodium Salt

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
20 °C

実験手順

A solution of (S)-enriched ibuprofen having an enantiomeric purity of 95.5% (211 kg) in toluene (797 kg) was heated to 60° C. with water (300 l) and aqueous sodium hydroxide solution (52 l--specific gravity 1.5) and allowed to settle for four hours. The aqueous layer was separated and the toluene layer washed with water. The aqueous washings and the aqueous layer were combined and residual toluene removed by distillation. Acetone (1684 kg) was added and the mixture cooled to 20° C. The sodium salt of (S)-enriched ibuprofen dihydrate (having an enantiomeric purity of 99.9%) separated, was collected by filtration and dried in vacuo. (Yield 143.5 kg).

後処理

  1. customThe aqueous layer was separated
  2. washthe toluene layer washed with water
  3. customresidual toluene removed by distillation
  4. additionAcetone (1684 kg) was added
  5. customseparated
  6. filtrationwas collected by filtration
  7. customdried in vacuo

出典と根拠

ORDレコード
ord-89028e78ed534db184de502b0bf84df7
出典データセット
uspto-grants-1997_02
特許番号
US05599969

関連ノート

読み込み中…