HCID 67646998、化合物 → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1450099ノート

反応式

HRID 1450099 の反応式
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

参加物

4

反応物 1

HCID 67646998HCID 67646998、化合物

生成物 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine収率 35.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 arm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

後処理

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

出典と根拠

ORDレコード
ord-1c5f3cedde6f49e5b85f80ea76afab0a
出典データセット
uspto-grants-1997_02
特許番号
US05599816

反応ノート

読み込み中…