Water → Methyl phenethylcarbamate

HRID 1450271

反応式

HRID 1450271 の反応式
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(CC)CC)C.Cl[CH2:18][O:19][CH:20]=[O:21].O>O1CCCC1>[CH3:18][O:19][C:20]([NH:9][CH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)=[O:21]

参加物

6

反応物 4

HCID 962WaterHCID 1001PhenethylamineHCID 8471TriethylamineHCID 17803410Chloromethyl formate

生成物 1

HCID 4380476Methyl phenethylcarbamate収率 97.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a cold solution consisting of phenethylamine (20g,0.16mol) in tetrahydrofuran (900 mL) was added triethylamine (23 mL, 0.16 mol). To this solution was added dropwise chloromethylformate (64 mL, 0.8 mol). The reaction mixture was then stirred overnight water (450 mL) was added and the layers were separated. The organic layer was washed successively with water (1×200mL) and brine (1×200mL). The organic solvent was dried (anhydrous magnesium sulfate), filtered and concentrated to give the title compound (28 g, 94% yield).

後処理

  1. additionwas added
  2. customthe layers were separated
  3. washThe organic layer was washed successively with water (1×200mL) and brine (1×200mL)
  4. dry with materialThe organic solvent was dried (anhydrous magnesium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-7ba537965e054dbcaf88d63a2f6e216f
出典データセット
uspto-grants-1997_02
特許番号
US05602145

関連ノート

読み込み中…