Sodium Iodide → 4-(3-Iodopropoxy)benzoic acid, methyl ester
反応式
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][CH:7]=1.[I-:16].[Na+]>CC(C)=O.C(OCC)C>[I:16][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][CH:7]=1参加物
5
実験手順
Dissolve 4-(3-chloropropoxy)benzoic acid, methyl ester (6.97 g, 30.5 mmol) in anhydrous acetone (100 mL) and add powdered sodium iodide (16.0 g, 107 mmol). Heat at reflux under an argon atmosphere for 38 hours. Dilute with ethyl ether (100 mL) and filter through Celite® filter aid. Wash the filtrate with water and brine, then dry (MgSO4). Evaporate the solvent in vacuo to give 4-(3iodopropoxy)benzoic acid, methyl ester as a yellow oil.
後処理
- temperatureHeat
- temperatureat reflux under an argon atmosphere for 38 hours
- filtrationfilter through Celite®
- filtrationfilter aid
- washWash the filtrate with water and brine
- dry with materialdry (MgSO4)
- customEvaporate the solvent in vacuo
出典と根拠
- ORDレコード
- ord-892327d762e84237b0de3bfdce4143dc
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05602147
反応ノート
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