Acetic Acid → 2-Chloro-N4-(2-methylpropyl)-3,4-quinolinediamine

HRID 1450689ノート

反応式

HRID 1450689 の反応式
[Cl:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]([NH:15][CH2:16][CH:17]([CH3:19])[CH3:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.C(O)(=O)C.[H][H]>[Pt].C(O)(C)C>[Cl:1][C:2]1[C:11]([NH2:12])=[C:10]([NH:15][CH2:16][CH:17]([CH3:19])[CH3:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

6

反応物 3

HCID 176Acetic AcidHCID 109348134-Quinolinamine, 2-chloro-N-(2-methylpropyl)-3-nitro-HCID 178418361HCID 178418361、化合物

生成物 1

HCID 117470392-Chloro-N4-(2-methylpropyl)-3,4-quinolinediamine収率 73%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 3776Isopropanol溶媒

実験手順

A solution of 2-chloro-N-(2-methylpropyl)-3-nitro-4-quinolinamine (120 g), acetic acid (300 mL), isopropyl alcohol (300 mL), and 5% platinum on carbon (7.2 g) was allowed to stand at room temperature for 30 h under 2 bars of hydrogen pressure. The resulting solution was filtered, and the solvent was removed from the filtrate at reduced pressure. The residue was dissolved in aqueous hydrochloric acid (1 L, 4N). The product was precipitated by adding this solution to a solution of sodium hydroxide. The precipitate was filtered and washed with water to afford the product 2-chloro-N4 -(2-methylpropyl)-3,4-quinolinediamine in 73% yield.

後処理

  1. filtrationThe resulting solution was filtered
  2. customthe solvent was removed from the filtrate at reduced pressure
  3. dissolutionThe residue was dissolved in aqueous hydrochloric acid (1 L, 4N)
  4. customThe product was precipitated
  5. additionby adding this solution to a solution of sodium hydroxide
  6. filtrationThe precipitate was filtered
  7. washwashed with water

出典と根拠

ORDレコード
ord-10bf16a5080d45259515b9e1a54ce271
出典データセット
uspto-grants-1997_02
特許番号
US05602256

反応ノート

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