Imidazole → HCID 53792902、化合物

HRID 1451034ノート

反応式

HRID 1451034 の反応式
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([CH:12]([CH3:14])[CH3:13])[N:3]=1.[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1>C(#N)C>[N:15]1([C:2]2[N:7]=[C:6]([N:15]3[CH:19]=[CH:18][N:17]=[CH:16]3)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([CH:12]([CH3:14])[CH3:13])[N:3]=2)[CH:19]=[CH:18][N:17]=[CH:16]1

参加物

4

反応物 2

HCID 795ImidazoleHCID 214450712,4-Dichloro-5-nitro-6-(propan-2-yl)pyrimidine

生成物 1

HCID 53792902HCID 53792902、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Combine 29 g (0.12 mol) of 2,4-dichloro-5-nitro-6-(2-propyl)-pyrimidine with 42 g (0.62 mol) of imidazole in 500 mL of acetonitrile, and stir at room temperature for 24 h. Remove the solvent under vacuum, slurry the residue in 500 mL of CH2Cl2 and wash with 4×500 mL 10% K2CO3. Dry the organic portion over MgSO4, treat with charcoal, filter and concentrate the filtrate to dryness under vacuum to afford 2,4-bis(1H-imidazol-1-yl)-5-nitro-6-(2-propyl)pyrimidine.

後処理

  1. customRemove the solvent under vacuum
  2. washwash with 4×500 mL 10% K2CO3
  3. dry with materialDry the organic portion over MgSO4
  4. additiontreat with charcoal
  5. filtrationfilter
  6. concentrationconcentrate the filtrate to dryness under vacuum

出典と根拠

ORDレコード
ord-e47a316cec55421fabd4a4b1aba174db
出典データセット
uspto-grants-1997_02
特許番号
US05602252

反応ノート

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