Sodium Hydroxide → 3-Aminomethylbenzoic acid hydrate
反応式
Cl.[NH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>>[OH2:8].[NH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8]参加物
3
実験手順
A mixture of methyl 3-aminomethylbenzoate hydrochloride (2.014 g, 0.0098 mol) in 1N sodium hydroxide (25 mL, 0.025 mol) was stirred at room temperature for 4 h. The mixture was neutralized with Dowex-H+ resin. The mixture was filtered and acetone (400 mL) was added to the filtrate. The white precipitate was collected by filtration and recrystallized from water-acetone to give 0.80 g of the title compound as a white powder, mp 278°-280° C.
後処理
- filtrationThe mixture was filtered
- additionacetone (400 mL) was added to the filtrate
- filtrationThe white precipitate was collected by filtration
- customrecrystallized from water-acetone
出典と根拠
- ORDレコード
- ord-94ff83784eb24d4b963ddcaf7afab86b
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05602277
反応ノート
読み込み中…