Hydrochloric Acid → 3-amino-4-(methylcarbamoyl)benzoic Acid
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([NH:14][CH3:15])=[O:13])[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>C(O)(=O)C>[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([NH:14][CH3:15])=[O:13])[C:5]([OH:7])=[O:6]参加物
5
実験手順
A mixture of methyl 3-amino-4-(methylamino)carbonylbenzoate (0.624 g, 0.003 mol) and 1N sodium hydroxide (4.5 mol, 0.0045 mol) was stirred at room temperature for 4 h. The mixture was neutralized with concentrated hydrochloric acid and then acetic acid was added to bring the pH close to 3. The precipitate obtained was collected by filtration, washed with water, and dried under vacuum over acetone for 24 h to give 0.4 g (69%) of 3-amino-4-(methylamino)carbonylbenzoic acid as a pale yellow powder, mp 215°-217° C.
後処理
- customclose to 3
- customThe precipitate obtained
- filtrationwas collected by filtration
- washwashed with water
- dry with materialdried under vacuum over acetone for 24 h
出典と根拠
- ORDレコード
- ord-2c6a40e6e46944d48ca1a4586a668851
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05602277
反応ノート
読み込み中…