化工社化工社 化学情報印刷レポート · 研究参考用
Triethyl Phosphate → Fludarabine Phosphate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethyl Phosphate | HCID 6535 | — |
| 反応物 | Trimethyl Phosphate | HCID 10541 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Fludarabine | HCID 657237 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Fludarabine Phosphate | HCID 30751 | — |
反応手順
Phosphorylation: The product from step (e) is mixed with phosphorous oxychloride in an alkyl phosphate such as triethylphosphate, or trimethylphosphate, followed by hydrolysis in water to yield the prodrug 9-β-D-arabinofuranosyl-2-fluoroadenine-5'-phosphate or fludarabine phosphate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05602246 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-3d182ccd67e644cba57efc186652ac7e |
| 出典メモ | uspto-grants-1997_02 |