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HRID1451116

反应详情

EQUATION

反应方程式

HRID 1451116 的结构方程式

REACTANTS

反应物

4
结构：CCOP(=O)(OCC)OCC
HCID6535

Triethyl phosphate

C6H15O4P

结构：COP(=O)(OC)OC
HCID10541

Trimethyl orthophosphate

C3H9O4P

结构：O=P(Cl)(Cl)Cl
HCID24813

Phosphoric trichloride

Cl3OP

结构：Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
HCID657237

Fludarabine

C10H12FN5O4

PRODUCTS

生成物

1
结构：Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O
HCID30751

Fludarabine phosphate

C10H13FN5O7P

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Phosphorylation: The product from step (e) is mixed with phosphorous oxychloride in an alkyl phosphate such as triethylphosphate, or trimethylphosphate, followed by hydrolysis in water to yield the prodrug 9-β-D-arabinofuranosyl-2-fluoroadenine-5'-phosphate or fludarabine phosphate.