2-Chlorobenzoyl chloride → HCID 19973948、化合物

反応式

[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH2:11][C:12]([C:21]1[N:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[N:22]=1)([CH:18]([CH3:20])[CH3:19])[C:13]([O:15][CH2:16][CH3:17])=[O:14].C(N(C(C)C)C(C)C)C>C(OCC)(=O)C>[CH3:20][CH:18]([CH3:19])[C:12]([C:21]1[N:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[N:22]=1)([NH:11][C:4](=[O:5])[C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[Cl:1])[C:13]([O:15][CH2:16][CH3:17])=[O:14]

参加物

実験手順

2-Chlorobenzoyl chloride (0.35 g) in ethyl acetate (3 ml) was added to a stirred solution of ethyl 2-amino-3-methyl-2-(4,6-dimethoxypyrimidin-2-yl)butanoate (0.566 g) and ethyl diisopropylamine (0.258 g) in ethyl acetate (15 ml). The mixture was stirred at room temperature for 2 hours, filtered, and the filtrate was washed with water, dried and evaporated to dryness under vacuum. The residual solid was triturated with 60°-80° petroleum ether to give 0.4 g of the desired product as a white solid, mp 94°-95° C.