HCID 11088367、化合物 → HCID 19974099、化合物

HRID 1451359ノート

反応式

HRID 1451359 の反応式
[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].C[O:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1>Br>[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].[OH:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1

参加物

3

反応物 1

HCID 11088367HCID 11088367、化合物

生成物 1

HCID 19974099HCID 19974099、化合物収率 15%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度
115 °C

実験手順

A mixture of 9-methoxy-thiazolo[3,2-b]isoquinolinium perchlorate (7 g, 22.19 mmol) in 100 ml of 48% HBr was heated for 18 hours at 115° C. The mixture was concentrated in vacuo, the residue was dissolved in warm water and filtered. The filtrate was treated with sodium perchlorate, the resulting solid was filtered, and washed with water to afford 1.0 g (15%) of 9-hydroxy-thiazolo[3,2-b]isoquinolinium perchlorate (Formula II: A=thiazolo; R1 =H; R6 =9-OH; X- =ClO4-).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutionthe residue was dissolved in warm water
  3. filtrationfiltered
  4. additionThe filtrate was treated with sodium perchlorate
  5. filtrationthe resulting solid was filtered
  6. washwashed with water

出典と根拠

ORDレコード
ord-ef88c70a30c64e83b2f689109e61ec5f
出典データセット
uspto-grants-1997_02
特許番号
US05604224

反応ノート

読み込み中…