Ammonia → 4-Thiazolemethanol, alpha-(bromomethyl)-2-(trifluoromethyl)-
反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9][Br:10])[N:7]=1.[BH4-].[Na+].Cl.N>CO>[F:13][C:2]([F:1])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]([OH:11])[CH2:9][Br:10])[N:7]=1参加物
6
反応条件
- 温度
- 10 °C
実験手順
6 g (0.022 mol) of 2-Trifluoromethyl-4-bromoacetyl-thiazole are dissolved in 150 ml of methanol, and the solution is cooled to 10° C. and 0.63 g of sodium borohydride is added. After 15 minutes ice is added, and the mixture is acidified with hydrochloric acid, made alkaline with ammonia and extracted by shaking with methylene chloride. The organic phase is dried over sodium sulphate, filtered and concentrated. An oil is obtained and is reacted further as the crude product.
後処理
- additionAfter 15 minutes ice is added
- extractionextracted
- dry with materialThe organic phase is dried over sodium sulphate
- filtrationfiltered
- concentrationconcentrated
- customAn oil is obtained
出典と根拠
- ORDレコード
- ord-da46e8d8a42d419fa1ec06949cf3316d
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05604225
反応ノート
読み込み中…