Sodium Hydroxide → HCID 14076219、化合物

HRID 1451402ノート

反応式

HRID 1451402 の反応式
[C:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][CH2:15][CH:16]([OH:27])[C:17]2[S:21][C:20]([NH:22][C:23](=[O:25])[CH3:24])=[N:19][C:18]=2[CH3:26])=[CH:8][CH:7]=1)([O:3]CC)=[O:2].[OH-].[Na+]>>[C:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][CH2:15][CH:16]([OH:27])[C:17]2[S:21][C:20]([NH:22][C:23](=[O:25])[CH3:24])=[N:19][C:18]=2[CH3:26])=[CH:8][CH:7]=1)([OH:3])=[O:2]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 14076218HCID 14076218、化合物

生成物 1

HCID 14076219HCID 14076219、化合物

実験手順

Prepared analogously to Example 2 by reaction of N-[2-(4-carboethoxyphenyl)ethyl]-2-hydroxy-2-(2-acetylamino-4-methyl-thiazol-5-yl)ethanamine with 1N sodium hydroxide solution. After neutralisation with 1N hydrochloric acid, the mixture is evaporated to dryness, and the residue is recrystallised from 10 ml of water.

後処理

  1. customAfter neutralisation with 1N hydrochloric acid, the mixture is evaporated to dryness
  2. customthe residue is recrystallised from 10 ml of water

出典と根拠

ORDレコード
ord-21ab236f2fcd49ddb3f1fdee9981f9fc
出典データセット
uspto-grants-1997_02
特許番号
US05604225

反応ノート

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