Sodium Hydroxide → N-[2-(4-Carboxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

HRID 1451408ノート

反応式

HRID 1451408 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:26])[C:17]2[N:18]=[C:19]([C:22]([F:25])([F:24])[F:23])[S:20][CH:21]=2)[CH3:13])=[CH:7][CH:6]=1)([O:3]C)=[O:2].[OH-].[Na+]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:26])[C:17]2[N:18]=[C:19]([C:22]([F:24])([F:23])[F:25])[S:20][CH:21]=2)[CH3:13])=[CH:7][CH:6]=1)([OH:3])=[O:2]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 19974173N-[2-(4-Carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

生成物 1

HCID 14076229N-[2-(4-Carboxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

実験手順

Prepared analogously to Example 2 by reaction of N-[2-(4-carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1N sodium hydroxide solution. After neutralisation with hydrochloric acid, the mixture is evaporated to dryness and the residue is treated with a mixture of ethyl acetate/ethanol=6:1. The extract is evaporated to dryness and the residue is triturated with 5 ml of water. The water is decanted off and the remaining residue is taken up in methanol, the solution is evaporated to dryness, and the residue is triturated with ether and filtered off with suction.

後処理

  1. customAfter neutralisation with hydrochloric acid, the mixture is evaporated to dryness
  2. additionthe residue is treated with a mixture of ethyl acetate/ethanol=6:1
  3. customThe extract is evaporated to dryness
  4. customthe residue is triturated with 5 ml of water
  5. customThe water is decanted off
  6. customthe solution is evaporated to dryness
  7. customthe residue is triturated with ether
  8. filtrationfiltered off with suction

出典と根拠

ORDレコード
ord-037e7ab42af14478b316274323077ea6
出典データセット
uspto-grants-1997_02
特許番号
US05604225

反応ノート

読み込み中…