Sodium Hydroxide → 4-(3-Bromopropoxy)aniline

HRID 1451643ノート

反応式

HRID 1451643 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12]C(=O)C)=[CH:8][CH:7]=1.[OH-].[Na+]>Cl>[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10849771N-[4-(3-bromopropoxy)phenyl]acetamide

生成物 1

HCID 199745634-(3-Bromopropoxy)aniline

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of the product of part (i) above (13 g) and 5N hydrochloric acid (200 ml) was heated under reflux for 2 h. After cooling, the mixture was basified with sodium hydroxide solution and extracted with dichloromethane. The organic phase was evaporated to give the title compound (7 g) as an oil. IR includes a peak at 3360-3450 cm-1 (NH).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. temperatureAfter cooling
  4. extractionextracted with dichloromethane
  5. customThe organic phase was evaporated

出典と根拠

ORDレコード
ord-844f3f95de144ec39e3629178d3a957b
出典データセット
uspto-grants-1997_02
特許番号
US05604237

反応ノート

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