Water → HCID 19972899、化合物

HRID 1451927ノート

反応式

HRID 1451927 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([C:10]3([C:17](=[S:20])[NH:18][CH3:19])[CH2:15][CH2:14][CH2:13][CH2:12][C:11]3=[O:16])=[CH:6][N:5]2[CH:21]=1.[BH4-].[Na+].O>CO>[OH:16][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][C:10]1([C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:21]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1)[C:17](=[S:20])[NH:18][CH3:19]

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 19972896N-Methyl-1-(2-methylimidazo[1,2-a]pyridin-6-yl)-2-oxocyclohexanecarbothioamide

生成物 1

HCID 19972899HCID 19972899、化合物収率 41%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3.03 g of 1-(2-methylimidazo[1,2-a ]pyridin-6-yl)-N-methyl-2-oxocyclohexanecarbothioamide was suspended in 30 ml of methanol. The obtained suspension was cooled with ice, followed by the addition of 0.15 g of sodium borohydride. The obtained mixture was stirred for one hour, followed by the addition of 50 ml of water. The insoluble matter was recovered by filtration and recrystallized from ethanol and then from acetonitrile to give 1.24 g of the title compound (white powder) as a single diastereomer (yield: 41%).

後処理

  1. temperatureThe obtained suspension was cooled with ice
  2. filtrationThe insoluble matter was recovered by filtration
  3. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-808f26e9213b4a4c8a95d523e0ffc932
出典データセット
uspto-grants-1997_02
特許番号
US05605907

反応ノート

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