Water → Imidazo[1,2-a]pyridin-6-ylmethanol

HRID 1452035

反応式

HRID 1452035 の反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH:10]=[O:11])[CH:7]=[CH:6][C:5]=12.[BH4-].[Na+].O.ClCCl.CO>CO>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][OH:11])[CH:7]=[CH:6][C:5]=12

参加物

6

反応物 4

HCID 962WaterHCID 4311764Sodium borohydrideHCID 7164582Imidazo[1,2-a]pyridine-6-carbaldehydeHCID 21226129Dichloromethane methanol

生成物 1

HCID 7060530Imidazo[1,2-a]pyridin-6-ylmethanol収率 57%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

0.90 g of the 6-imidazo[1,2-a]pyridinecarbaldehyde prepared in the Preparative Example 5 was dissolved in 20 ml of methanol. The obtained solution was stirred under cooling with ice, followed by the addition of 90 mg of sodium borohydride. The obtained mixture was stirred for 50 minutes, followed by the addition of water. The obtained mixture was extracted with chloroform. The organic phase was dried over anhydrous magnesium sulfate and distilled to remove the solvent. The obtained residue was purified by silica gel column chromatography [solvent: dichloromethane/methanol (30:1 to 10:1) to give 0.52 g of the title compound as a faintly orange-yellow solid (yield: 57%).

後処理

  1. temperatureunder cooling with ice
  2. stirringThe obtained mixture was stirred for 50 minutes
  3. extractionThe obtained mixture was extracted with chloroform
  4. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
  5. distillationdistilled
  6. customto remove the solvent
  7. customThe obtained residue was purified by silica gel column chromatography [solvent

出典と根拠

ORDレコード
ord-7df57b28d5884f26b1638b10098d8457
出典データセット
uspto-grants-1997_02
特許番号
US05606061

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