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Sulfuric Acid → 1-bromo-3-ethyl-5-nitroBenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 2-Bromo-4-ethyl-6-nitroaniline | HCID 19973468 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-bromo-3-ethyl-5-nitroBenzene | HCID 18929870 | — |
反応手順
Dissolve 4-ethyl-2-nitro-6-bromoaniline (6.62g, 27mmol) in ethanol (40mL). Add, by dropwise addition, concentrated sulfuric acid (5mL) and heat at reflux, adding sodium nitrite (4.55g, mmol) in small portions over 25 minutes. Stir at room temperature for several hours, pour onto ice and extract into ethyl acetate. Wash with water (3×) and brine (3×). Dry (MgSO4) and evaporate the solvent in vacuo and purify by silica gel chromatography to give 3-bromo-5-ethylnitrobenzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05606063 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-3537f4ef0a8b4604818f49ac23273f0b |
| 出典メモ | uspto-grants-1997_02 |