反应详情

Dissolve 4-ethyl-2-nitro-6-bromoaniline (6.62g, 27mmol) in ethanol (40mL). Add, by dropwise addition, concentrated sulfuric acid (5mL) and heat at reflux, adding sodium nitrite (4.55g, mmol) in small portions over 25 minutes. Stir at room temperature for several hours, pour onto ice and extract into ethyl acetate. Wash with water (3×) and brine (3×). Dry (MgSO4) and evaporate the solvent in vacuo and purify by silica gel chromatography to give 3-bromo-5-ethylnitrobenzene.

1. temperatureheat
2. temperatureat reflux
3. additionpour onto ice
4. extractionextract into ethyl acetate
5. washWash with water (3×) and brine (3×)
6. dry with materialDry (MgSO4)
7. customevaporate the solvent in vacuo
8. custompurify by silica gel chromatography