1-bromo-3-ethyl-5-nitroBenzene → 3-Bromo-5-ethylaniline
反応式
[Br:1][C:2]1[CH:3]=[C:4]([N+:10]([O-])=O)[CH:5]=[C:6]([CH2:8][CH3:9])[CH:7]=1>C(O)(=O)C.C(O)C.[Fe]>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([CH2:8][CH3:9])[CH:7]=1)[NH2:10]参加物
5
実験手順
Dissolve 3-bromo-5-ethylnitrobenzene (6.21g, 27mmol) in acetic acid (40mL) and ethanol (30mL) and treat with iron powder (2.7g). Reflux for 3 hours, filter through Celite and evaporate the solvent in vacuo. Purify by silica gel chromatography to give 3-bromo-5-ethylaniline.
後処理
- temperatureReflux for 3 hours
- filtrationfilter through Celite
- customevaporate the solvent in vacuo
- customPurify by silica gel chromatography
出典と根拠
- ORDレコード
- ord-b46620aeb06f4cf682d50726ac488bb8
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05606063
反応ノート
読み込み中…