Oxalyl chloride → 4-Fluorobenzoyl isocyanate

HRID 1452516

反応式

HRID 1452516 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.C(Cl)(=O)[C:12](Cl)=[O:13]>ClCCl>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:8]=[C:12]=[O:13])=[O:7])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 715724-Fluorobenzamide

生成物 1

HCID 27333754-Fluorobenzoyl isocyanate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.5 g of 4-fluorobenzamide was dissolved in 20 ml of dichloromethane and 2.3 ml of oxalyl chloride was slowly added thereto at room temperature, and then the mixutre was heated and refluxed for 16 hours. When the reaction was completed, the reaction mixture was cooled to room temperature and the solvent was distilled under reduced pressure to produce the titled compound as a oil. Without purification processes, next process was proceeded.

後処理

  1. temperaturerefluxed for 16 hours
  2. temperaturethe reaction mixture was cooled to room temperature
  3. distillationthe solvent was distilled under reduced pressure

出典と根拠

ORDレコード
ord-6f7e71e2837f4a44b05ef245dccab01d
出典データセット
uspto-grants-2009_01
特許番号
US07473700B2

関連ノート

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