Benzenesulfonyl chloride → N-(4-bromophenyl)-N-methylbenzenesulfonamide
反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([NH:6][CH3:7])=[CH:4][CH:3]=1.[C:10]1([S:16](Cl)(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([N:6]([CH3:7])[S:16]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:18])=[O:17])=[CH:4][CH:3]=1参加物
4
実験手順
A solution of 0.61 g (3.3 mmol) of 4-bromo-N-methylaniline and 0.5 mL (3.92 mmol) of benzenesulfonyl chloride in 5 mL of pyridine was stirred for 12 h at rt. After that time the pyridine was removed by azeotropic distillation with heptane. The residue was purified by chromatography on silica (hexanes:EtOAc, 9:1) to give the title compound.
後処理
- customAfter that time the pyridine was removed by azeotropic distillation with heptane
- customThe residue was purified by chromatography on silica (hexanes:EtOAc, 9:1)
出典と根拠
- ORDレコード
- ord-f892dc2dce5e43e4bef01bc57c7e2192
- 出典データセット
- uspto-grants-2009_01
- 特許番号
- US07473703B2
反応ノート
読み込み中…