Benzyl chloroformate → [3-Fluoro-4-(4-methyl-[1,2,3]triazol-1-yl)-phenyl]-carbamic acid benzyl ester
反応式
[F:1][C:2]1[CH:3]=[C:4]([NH2:14])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([CH3:13])[N:10]=[N:9]1.Cl[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17]>>[CH2:19]([O:18][C:16](=[O:17])[NH:14][C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[N:9]2)=[C:2]([F:1])[CH:3]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1参加物
3
実験手順
3-Fluoro-4-(4-methyl-[1,2,3]triazol-1-yl)-phenylamine (Intermediate 21) (34.8 g, 0.181 mol) and benzyl chloroformate (34 mL, 0.238 mol) were reacted following the procedure for Intermediate 26. The crude product obtained by filtration was dried in vacuo and triturated with chloroform/hexanes (250 ml/500 ml) to give the title compound as a colourless solid (56 g).
後処理
- customThe crude product obtained by filtration
- customwas dried in vacuo