N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide → 2-Amino-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([NH:13][CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:16][CH2:15]1)=[O:12])([O-])=O>CC1CCCO1.[Pt](=O)=O>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([NH:13][CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:16][CH2:15]1)=[O:12]参加物
4
実験手順
20.00 g (56.59 mmol, 1.0 eq) 2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide from Example 1 are placed in 280 mL 2-methyltetrahydrofuran. The solution is hydrogenated in the presence of 2.00 g platinum dioxide at 20° C. The catalyst is filtered off and washed with 20 ml of 2-methyltetrahydrofuran. The product is not isolated, but used as a solution in the next step.