Trimethylsilyl iodide → HCID 178434305、化合物

HRID 1452835

反応式

HRID 1452835 の反応式
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S:27]([CH3:30])(=[O:29])=[O:28])(=[O:20])=[O:19])=[CH:14][CH:15]=2)[C:10]([CH3:31])=[N:9]1)=O)(C)(C)C.I[Si](C)(C)C>C(Cl)(Cl)Cl>[CH3:30][S:27]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[S:18]([NH:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[NH:8][N:9]=[C:10]2[CH3:31])(=[O:20])=[O:19])(=[O:28])=[O:29]

参加物

4

反応物 2

HCID 85247Trimethylsilyl iodideHCID 22567145N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide

生成物 1

HCID 178434305HCID 178434305、化合物収率 30.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

2-Methylsulfonyl-N-(3-methyl-1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 6 from 1.45 g of N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide, 12.6 ml of chloroform and 0.44 ml of iodotrimethylsilane. 0.35 g of 2-methylsulfonyl-N-(3-methyl-1H-indazol-5-yl)benzenesulfonamide is thus obtained in the form of a white solid melting above 260° C. (analysis: C15H15N3O4S2 % calculated C, 49.30; H, 4.14; N, 11.50; O, 17.51; S, 17.55. % found C, 48.99; H, 4.45; N, 11.67; S, 17.23).

出典と根拠

ORDレコード
ord-6cb8090cc00545dc8074af213bef2973
出典データセット
uspto-grants-2009_01
特許番号
US07473701B2

関連ノート

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