Methanol → Methyl 2-(2-aminobenzo[d]thiazol-6-yl)acetate

HRID 1452960

反応式

HRID 1452960 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][C:12]([OH:14])=[O:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.CO.Cl.O1CCOC[CH2:19]1>O1CCOCC1>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][C:12]([O:14][CH3:19])=[O:13])[CH:8]=[CH:7][C:5]=2[N:6]=1

参加物

5

反応物 3

HCID 887MethanolHCID 757163(2-Aminobenzothiazol-6-yl)acetic acidHCID 204431481,4-Dioxane hydrochloride

生成物 1

HCID 45077305Methyl 2-(2-aminobenzo[d]thiazol-6-yl)acetate収率 81%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
75 °C

実験手順

A mixture of 2-(2-aminobenzo[d]thiazol-6-yl)acetic acid (95%, 10.0 g, 45.6 mmol), methanol (50 mL), 4 N HCl/1,4-dioxane (12.0 mL, 48.0 mmol) in 1,4-dioxane (30 mL) was heated at 75° C. for 9 hr and then concentrated under vacuum. The residue was suspended into water (50 mL) and basified to pH 9 with 1N NaOH solution. The title compound (8.19 g, 81% yield) was collected as a pale solid by suction filtration and dried under vacuum at 50° C.

後処理

  1. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-2a65b4fc401246b08a268238481bcabf
出典データセット
uspto-grants-2009_01
特許番号
US07473784B2

関連ノート

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