5,6-Dichloro-1H-benzimidazole → HCID 178478377、化合物

HRID 1453558

反応式

HRID 1453558 の反応式
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[Cl:12][C:13]1[C:21]([Cl:22])=[CH:20][C:16]2[N:17]=[CH:18][NH:19][C:15]=2[CH:14]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:17]2[C:16]3[CH:20]=[C:21]([Cl:22])[C:13]([Cl:12])=[CH:14][C:15]=3[N:19]=[CH:18]2)[N:3]=1

参加物

4

反応物 2

HCID 3317755,6-Dichloro-1H-benzimidazoleHCID 53244122,6-Dichloropurine

生成物 1

HCID 178478377HCID 178478377、化合物収率 53.8%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

567 mg of 2,6-dichloropurine, 6 ml of butanol and 617 mg of 5,6-dichlorobenzimidazole are mixed and brought to a temperature of 100° C. for approximately 24 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with isopropanol and drying under vacuum at 50° C. are carried out, and 548 mg of expected product are obtained, in the form of gray/black-colored crystals.

後処理

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with isopropanol
  4. customdrying under vacuum at 50° C.

出典と根拠

ORDレコード
ord-76e0f40d11ff49809c50455260d74855
出典データセット
uspto-grants-2009_01
特許番号
US07476670B2

関連ノート

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