2,6-Dichloropurine → HCID 178506067、化合物

HRID 1453605ノート

反応式

HRID 1453605 の反応式
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[F:12][C:13]([F:24])([F:23])[C:14]1[CH:22]=[C:21]2[C:17]([CH2:18][CH2:19][NH:20]2)=[CH:16][CH:15]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:20]2[C:21]3[C:17](=[CH:16][CH:15]=[C:14]([C:13]([F:12])([F:23])[F:24])[CH:22]=3)[CH2:18][CH2:19]2)[N:3]=1

参加物

4

反応物 2

HCID 53244122,6-DichloropurineHCID 101764376-(Trifluoromethyl)indoline

生成物 1

HCID 178506067HCID 178506067、化合物収率 92.4%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

756 mg of 2,6-dichloropurine, 8 ml of butanol and 897 mg of 6-(trifluoromethyl)indoline are mixed and brought to a temperature of 90° C. for approximately 23 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with ethyl ether and drying under vacuum at 50° C. are carried out, and 1.256 g of expected product are obtained, in the form of beige crystals.

後処理

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with ethyl ether
  4. customdrying under vacuum at 50° C.

出典と根拠

ORDレコード
ord-7441ed4852aa4a509e750a4802b3e303
出典データセット
uspto-grants-2009_01
特許番号
US07476670B2

反応ノート

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