Sodium Hydroxide → 2-[(5-Chloro-thiophene-2-carbonyl)-amino]-propionic acid
反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH:10]([CH3:15])[C:11]([O:13]C)=[O:12])=[O:8])=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH:10]([CH3:15])[C:11]([OH:13])=[O:12])=[O:8])=[CH:4][CH:3]=1参加物
4
実験手順
3.80 g (15.3 mmol) methyl 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate are suspended in 15.5 ml (15.5 mmol) 1-molar aqueous sodium hydroxide solution, combined with 15 ml of ethanol and then stirred for 4 hours at ambient temperature. After evaporation i. vac. the residue is combined with ice water, extracted with diethyl ether, the aqueous phase is poured into an ice/acetic acid mixture and the resulting precipitate is suction filtered. After washing with water the precipitate is dried at 60° C.
後処理
- customAfter evaporation i
- extractionextracted with diethyl ether
- additionthe aqueous phase is poured into an ice/acetic acid mixture
- filtrationfiltered
- washAfter washing with water the precipitate
- customis dried at 60° C.
出典と根拠
- ORDレコード
- ord-95f30555959f40fc81f2285bbdf668e5
- 出典データセット
- uspto-grants-2009_01
- 特許番号
- US07476663B2
反応ノート
読み込み中…