Hydrochloric Acid → 6-[4-(3-aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine
反応式
Cl.C1(C(=[N:15][C:16]2[CH:17]=[C:18]([C:22]3[N:23]=[CH:24][N:25]([CH3:37])[C:26]=3[C:27]3[S:36][C:30]4[N:31]=[CH:32][N:33]=[C:34]([NH2:35])[C:29]=4[CH:28]=3)[CH:19]=[CH:20][CH:21]=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[NH2:15][C:16]1[CH:17]=[C:18]([C:22]2[N:23]=[CH:24][N:25]([CH3:37])[C:26]=2[C:27]2[S:36][C:30]3[N:31]=[CH:32][N:33]=[C:34]([NH2:35])[C:29]=3[CH:28]=2)[CH:19]=[CH:20][CH:21]=1参加物
4
実験手順
2M HCl (0.75 mL) was added to a solution of 6-(4-{3-[(diphenylmethylene)amino]phenyl}-1-methyl-1H-imidazol-5-yl)thieno[2,3-d]pyrimidin-4-amine (0.45 g) in THF (15 mL), stirred for 10 mins, then partitioned between water and EtOAc. The aqueous layer was separated, basified to pH9 with concentrated aqueous ammonia, extracted with DCM (3×30 mL), combined organics dried, filtered and concentrated in vacuo to give the title compound as a colourless solid (0.33 g, 100%);