Water → [(S)-2-(7-Aminomethyl-furo[2,3-g]indazol-1-yl)-1-methylethyl]-carbamic acid benzyl ester

A solution of the product from Step A (1.28 g, 3.17 mmol) in THF (25 mL) was stirred with polymer supported triphenylphosphine (4 eq, 3 mmol/g, 12.7 mmol, 4.23 g) at 50° C. for 2 hours. Water (2.5 mL) was added and the mixture was stirred for another hour; more water (5 mL) was added and the reaction mixture was filtered. The solids were washed well with THF and the filtrate was evaporated to a residue which was dried under a vacuum to give a foam (1.10 g, 92%): LC/MS m/z 379 [M+H]+.

1. customat 50° C.
2. customfor 2 hours
3. filtrationthe reaction mixture was filtered
4. washThe solids were washed well with THF
5. customthe filtrate was evaporated to a residue which
6. customwas dried under a vacuum

ORDレコード

ord-b81cadbfcf6c4366b5736bc29f75a63d

出典データセット

uspto-grants-2009_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07476687B2