Ammonium fluoride → 5-Ethyl-1H-indole
反応式
[CH2:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([Si](C(C)C)(C(C)C)C(C)C)[CH:7]=[CH:6]2)[CH3:2].[F-].[NH4+]>C1COCC1.CO>[CH2:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2)[CH3:2]参加物
5
実験手順
The Indole 9 (2.2 g, 7.29 mmol) was dissolved in THF (20 mL) and a solution of ammonium fluoride (NH4F; 1.4 g, 37.8 mmol) in MeOH (20 mL) was added and stirred for 72 hours at room temperature. The solvent was evaporated and the residue was dissolved in ethyl acetate. The organic layer was washed with 2N H3PO4, dried over MgSO4, filtered and evaporated to give compound 10 as an off white solid (1.06 g; M+1=146.2).
後処理
- customThe solvent was evaporated
- dissolutionthe residue was dissolved in ethyl acetate
- washThe organic layer was washed with 2N H3PO4
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-4759c4e1179d42e9ac10f5d158cad7b8
- 出典データセット
- uspto-grants-2009_01
- 特許番号
- US07476746B2
反応ノート
読み込み中…