Water → 4-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester

HRID 1454263ノート

反応式

HRID 1454263 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11](OS(C)(=O)=O)[CH2:10][CH:9]1[CH3:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].[N-:19]=[N+:20]=[N-:21].[Na+].O.CCCCCC.C(OCC)(=O)C>CN(C=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([N:19]=[N+:20]=[N-:21])[CH2:10][CH:9]1[CH3:18])=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 33557Sodium AzideHCID 197903964-Methanesulfonyloxy-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl EsterHCID 21226206Ethyl acetate hexane

生成物 1

HCID 140411954-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The 4-methanesulfonyloxy-2-methyl-pyrrolidine-1-carboxylic acid t-butyl ester (135.21 mg, 0.48 mmol) was taken up in dry DMF under argon and sodium azide (156.00 mg, 2.40 mmol) was added. The reaction was then heated to 60EC for 48 h. The reaction was poured into water and the aqueous layer was extracted three times with ethyl acetate. The combined organic layers were washed with sat NaHCO3 and brine then dried over MgSO4. The solution was filtered and the solvent removed under reduced pressure. The product was isolated by flash chromatography. (5:1 hexane-ethyl acetate) Yield 93.41 mg.

後処理

  1. temperatureThe reaction was then heated to 60EC for 48 h
  2. extractionthe aqueous layer was extracted three times with ethyl acetate
  3. washThe combined organic layers were washed with sat NaHCO3 and brine
  4. dry with materialthen dried over MgSO4
  5. filtrationThe solution was filtered
  6. customthe solvent removed under reduced pressure
  7. customThe product was isolated by flash chromatography

出典と根拠

ORDレコード
ord-753b7336246841b09722bb705939086c
出典データセット
uspto-grants-2009_01
特許番号
US07479495B2

反応ノート

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