Ketamine → Esmolol

HRID 1454323

反応式

HRID 1454323 の反応式
[CH:1]1C=CC(SC[C@H]2O[C@@H](N3C4=NC=NC(N[C@H]5[C@H](O)CCC5)=C4N=C3)[C@H](O)[C@@H]2O)=C(F)C=1.CNC1(C2C=CC=CC=2Cl)C(=O)CCCC1.CC1C=CC=C(C)C=1NC1SCCCN=1.CC(C1C=CC2SC3C=CC=CC=3N(CCCN(C)C)C=2C=1)=O.[CH:87](/[C:92](O)=O)=[CH:88]/[C:89]([OH:91])=[O:90].[CH3:95][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105]C(CCOC)=[CH:107][CH:108]=1)[CH3:97].CC(NCC(O)COC1C=CC=C2C=CC=CC=12)C>CS(C)=O>[CH3:97][CH:96]([NH:98][CH2:99][CH:100]([OH:113])[CH2:101][O:102][C:103]1[CH:104]=[CH:105][C:92]([CH2:87][CH2:88][C:89]([O:91][CH3:1])=[O:90])=[CH:107][CH:108]=1)[CH3:95]

参加物

8

反応物 6

HCID 3821KetamineHCID 4171MetoprololHCID 4946PropranololHCID 5707XylazineHCID 6420038Acepromazine MaleateHCID 11561692Gs-9667

生成物 1

HCID 59768Esmolol

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Rats (Sprague Dawley) weighing 300-400 gms were purchased from Simonsen laboratories. CVT-3619 was dissolved in DMSO and further diluted in saline. CVT-510 was dissolved in saline. Ketamine was purchased from Fort Dodge Animal Health, Xylazine from Bayer and Acepromazine Maleate from Fermenta Animal Health Co. Metoprolol and propranolol were purchased from SIGMA. Esmolol was obtained from a local pharmacy.

後処理

  1. additionfurther diluted in saline
  2. dissolutionCVT-510 was dissolved in saline

出典と根拠

ORDレコード
ord-4b75149209604688b19e1400bc412ecb
出典データセット
uspto-grants-2009_01
特許番号
US07479485B2

関連ノート

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