N-bromobutanimide → Methyl 3-bromo-5-formyl-4-hydroxybenzoate

反応式

[CH:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[OH:13])[C:6]([O:8][CH3:9])=[O:7])=[O:2].[Br:14]N1C(=O)CCC1=O>>[Br:14][C:11]1[CH:10]=[C:5]([CH:4]=[C:3]([CH:1]=[O:2])[C:12]=1[OH:13])[C:6]([O:8][CH3:9])=[O:7]

参加物

反応物 2

HCID 67184N-bromobutanimide

HCID 212595Benzoic acid, 3-formyl-4-hydroxy-, methyl ester

生成物 1

HCID 71711084Methyl 3-bromo-5-formyl-4-hydroxybenzoate収率 73%

実験手順

Proceeding as in Reference 9, but substituting methyl 3-formyl4-hydroxybenzoate (12.0 g, 66.6 mmol, 1 eq.) and N-bromosuccinimide (12.45 g, 69.9 mmol, 1.05 eq.) gave methyl 3-bromo-5-formyl-4-hydroxybenzoate (12.6 g) as a white solid.

出典と根拠

ORDレコード: ord-379cf9647cd345568c657c7fabff09c7
出典データセット: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07479502B2

反応ノート

読み込み中…