Hydrochloric Acid → HCID 68680811、化合物

HRID 1454564ノート

反応式

HRID 1454564 の反応式
[Si](O[CH2:9][CH2:10][CH2:11][N:12]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH:19]([O:22]C)OC)[C:13]1=[O:24])(C(C)(C)C)(C)C.Cl.[NH:26]1[CH2:31][CH2:30][CH:29]([O:32][C:33](=[O:47])[NH:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[CH2:28][CH2:27]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>C(#N)C>[OH:22][CH2:19][CH2:18][CH2:17][N:14]1[CH2:15][CH2:16][N:12]([CH2:11][CH2:10][CH2:9][N:26]2[CH2:27][CH2:28][CH:29]([O:32][C:33](=[O:47])[NH:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH2:30][CH2:31]2)[C:13]1=[O:24]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 5049666Sodium triacetoxyborohydrideHCID 10851461Biphenyl-2-ylcarbamic Acid Piperidin-4-yl EsterHCID 68680479HCID 68680479、化合物

生成物 1

HCID 68680811HCID 68680811、化合物収率 52%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To crude 1-[3-(tert-butyldimethylsilanyloxy)propyl]-3-(3,3-dimethoxypropyl)imidazolidin-2-one (11.4 g, 32 mmol; prepared as described in Preparation 2) was added to a 1:1 mixture of 1N aqueous HCl (32 mL, 32 mmol, 1.0 eq) in ACN (32 mL). The reaction was allowed to stir at room temperature for 2 hours. To the reaction mixture was added biphenyl-2-ylcarbamic acid piperidin-4-yl ester (9.4 g, 32 mmol; prepared as described in Preparation 3) and was allowed to stir for 30 minutes, followed by the addition of NaBH(OAc)3 (20.3 g, 96 mmol). The reaction mixture was allowed to stir overnight. After overnight, the solution was concentrated in vacuo. The crude mixture was taken up in DCM (400 mL) and washed with 1N NaOH (200 mL), water (200 mL) and brine (200 mL). The organic phase was dried over MgSO4, filtered and concentrated then purified via silica gel chromatography (10% MeOH in DCM with 1% NH3(aq)) to afford the title compound (7.98 g, 16.6 mmol) in 52% yield.

後処理

  1. stirringto stir for 30 minutes
  2. stirringto stir overnight
  3. waitAfter overnight
  4. concentrationthe solution was concentrated in vacuo
  5. washwashed with 1N NaOH (200 mL), water (200 mL) and brine (200 mL)
  6. dry with materialThe organic phase was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customthen purified via silica gel chromatography (10% MeOH in DCM with 1% NH3(aq))

出典と根拠

ORDレコード
ord-6592dc33c1e44156a3aa09a458770ec2
出典データセット
uspto-grants-2009_01
特許番号
US07479562B2

反応ノート

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