Hydroxylamine → 51519-20-1

HRID 1454801ノート

反応式

HRID 1454801 の反応式
C[N:2](C)[CH:3]=[N:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1.N[OH:13]>O1CCCC1>[OH:13][NH:2][CH:3]=[N:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1

参加物

4

反応物 2

HCID 787HydroxylamineHCID 1222947551519-09-6

生成物 1

HCID 13560477151519-20-1

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
80 °C

実験手順

A solution of N,N-dimethyl-N′-pyrazin-2-ylimidoformamide (189 g) from Step A in tetrahydrofuran (400 mL) was treated drop wise with 50% aqueous solution of hydroxylamine (245.7 mL) at 0° C., then warmed up to 80° C. for 2.5 h. Tetrahydrofuran was removed by rotoevaporation and the resulting aqueous mixture kept cold in a refrigerator. The resulting solid was filtered and rinsed with cold diethyl ether to yield the desired product.

後処理

  1. customTetrahydrofuran was removed by rotoevaporation
  2. filtrationThe resulting solid was filtered
  3. washrinsed with cold diethyl ether

出典と根拠

ORDレコード
ord-354e37c2d3d34199aa47b4bed8435fd3
出典データセット
uspto-grants-2009_01
特許番号
US07482336B2

反応ノート

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