Sodium Hydroxide → 5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine
反応式
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH:16]C(=O)C(C)(C)C)=[N:13][C:14]=2[CH3:15])=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:16])=[N:13][C:14]=2[CH3:15])=[CH:23][CH:24]=1参加物
3
実験手順
This material was prepared in analogy to example 86 step B] from N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide (0.78 g) and 3M aqueous NaOH (3.93 mL) as an amorphous orange solid (0.58 g). MS (ESI): 247.2 (MH+).
出典と根拠
- ORDレコード
- ord-cfe4e35e0dd64635b46c4097642d8d26
- 出典データセット
- uspto-grants-2009_01
- 特許番号
- US07482341B2
反応ノート
読み込み中…