2,5-Dibromopyridine → 5-Bromo-2-(2,6-difluorobenzyl)pyridine

HRID 1454975ノート

反応式

HRID 1454975 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[Br-].[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:12]=1[CH2:13][Zn+]>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([CH2:13][C:12]2[C:11]([F:10])=[CH:18][CH:17]=[CH:16][C:15]=2[F:19])=[N:3][CH:4]=1

参加物

5

反応物 2

HCID 693532,5-DibromopyridineHCID 178505728HCID 178505728、化合物

生成物 1

HCID 575312355-Bromo-2-(2,6-difluorobenzyl)pyridine

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2,5-dibromopyridine (10 g) in THF was added Tetrakis (2.2 g) and 2,6-difluorobenzylzinc bromide (126 mL, 63 mmol). The reaction was heated to reflux until reaction was complete by TLC. The reaction was cooled to room temperature, filtered through celite, and concentrated in vacuo. The title compound was purified by silica gel (Hexanes/methylene chloride).

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux until reaction
  3. filtrationfiltered through celite
  4. concentrationconcentrated in vacuo
  5. customThe title compound was purified by silica gel (Hexanes/methylene chloride)

出典と根拠

ORDレコード
ord-32d5028e2bcb45509fcf0f3760b78004
出典データセット
uspto-grants-2009_01
特許番号
US07482345B2

反応ノート

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