Chloroform → HCID 178509715、化合物

HRID 1455304ノート

反応式

HRID 1455304 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:13]=[N:14][C:15]3[C:20]([CH:21]=2)=[N:19][CH:18]=[CH:17][CH:16]=3)([NH2:11])[CH2:9][NH2:10])=[CH:4][CH:3]=1.CO[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#N)[CH:27]=1)=[NH:25].C(Cl)(Cl)Cl>CO>[C:24]([C:26]1[CH:27]=[C:28]([C:32]2[NH:10][CH2:9][C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)([C:12]3[CH:13]=[N:14][C:15]4[C:20]([CH:21]=3)=[N:19][CH:18]=[CH:17][CH:16]=4)[N:11]=2)[CH:29]=[CH:30][CH:31]=1)#[N:25]

参加物

5

反応物 3

HCID 6212ChloroformHCID 220548441-(4-Fluorophenyl)-1-(1,5-naphthyridin-3-yl)-1,2-ethanediamineHCID 552656943-Cyano-benzimidic acid methyl ester

生成物 1

HCID 178509715HCID 178509715、化合物収率 33.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1-(4-fluorophenyl)-1-(1,5-naphthyridin-3-yl)-1,2-ethanediamine (17 mg) in methanol (1 mL) was added 3-cyanobenzeneimidic acid methyl ester (23 mg), and the mixture was stirred at room temperature for 19 hrs. To the reaction mixture was added chloroform and insolubles were removed by filtration, followed by concentration of the filtrate in vacuo. The residue was purified by preparative thin-layer chromatography (100% ethyl acetate) to give the objective compound (8.0 mg).

後処理

  1. customwere removed by filtration
  2. customThe residue was purified by preparative thin-layer chromatography (100% ethyl acetate)

出典と根拠

ORDレコード
ord-e8f64816e78c483b808fd7d4a5f7ff5d
出典データセット
uspto-grants-2009_01
特許番号
US07482358B2

反応ノート

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