Chloroform → HCID 178432502、化合物

HRID 1455305ノート

反応式

HRID 1455305 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)([NH2:12])[CH:9]([NH2:11])[CH3:10])=[CH:4][CH:3]=1.CO[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#N)[CH:25]=1)=[NH:23].C(Cl)(Cl)Cl>CO>[C:22]([C:24]1[CH:25]=[C:26]([C:30]2[NH:11][CH:9]([CH3:10])[C:8]([C:13]3[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=3)([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[N:12]=2)[CH:27]=[CH:28][CH:29]=1)#[N:23]

参加物

5

反応物 3

HCID 6212ChloroformHCID 218859191,1-Bis(4-fluorophenyl)-1,2-propanediamineHCID 552656943-Cyano-benzimidic acid methyl ester

生成物 1

HCID 178432502HCID 178432502、化合物収率 14%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1,1-bis(4-fluorophenyl)-1,2-propanediamine (50 mg) was dissolved in methanol (1 mL), and to the solution was added 3-cyanobenzeneimidic acid methyl ester (75 mg). The mixture was stirred at room temperature for 24 hrs. After chloroform (5 ml) was added to the reaction mixture, insolubles were removed by filtration. After concentrating the filtrate in vacuo, the obtained residue was purified by silica gel column chromatography (C-300; hexane: ethyl acetate=3:1→1:1) to give the objective compound (10 mg).

後処理

  1. customwere removed by filtration
  2. concentrationAfter concentrating the filtrate in vacuo
  3. customthe obtained residue was purified by silica gel column chromatography (C-300; hexane: ethyl acetate=3:1→1:1)

出典と根拠

ORDレコード
ord-002a05c7a5334da0a514b9167aa45dae
出典データセット
uspto-grants-2009_01
特許番号
US07482358B2

反応ノート

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