ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Methyltriphenylphosphonium iodide → benzyl (S)-1-((1S,2R,4R)-4-amino-2-ethylcyclohexyl)-2-oxopyrrolidin-3-ylcarbamate

HRID 1455407
ノート
印刷プレビュー

反応式

HRID 1455407 の反応式
[I-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C(OC(N1C(=O)[C@@H]2C[C@H]1CC[C@@H]2NC(OCC1C=CC=CC=1)=O)=O)(C)(C)C.[CH2:49]([O:56][C:57](=[O:81])[NH:58][C@H:59]1[CH2:63][CH2:62][N:61]([C@H:64]2[CH2:69][CH2:68][C@@H:67]([NH:70]C(OC(C)(C)C)=O)[CH2:66][C@H:65]2[CH2:78][CH3:79])[C:60]1=[O:80])[C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:70][C@@H:67]1[CH2:68][CH2:69][C@H:64]([N:61]2[CH2:62][CH2:63][C@H:59]([NH:58][C:57](=[O:81])[O:56][CH2:49][C:50]3[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=3)[C:60]2=[O:80])[C@H:65]([CH2:78][CH3:79])[CH2:66]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 638159Methyltriphenylphosphonium iodideHCID 68765971HCID 68765971、化合物HCID 68767907{(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-ethyl-cyclohexyl]-2-oxo-pyrrolidin-3-yl}-carbamic acid benzyl ester

生成物 1

HCID 86596874benzyl (S)-1-((1S,2R,4R)-4-amino-2-ethylcyclohexyl)-2-oxopyrrolidin-3-ylcarbamate

試薬・触媒・溶媒 1

HCID 21863450
Trifluoroacetic acid methylene chloride
溶媒

実験手順

Following the procedures described in Example 2a, Steps 1-4, and substituting methyl triphenylphosphonium iodide in Step 1, (1R,2S,5R)-2-benzyloxycarbonylamino-7-oxo-6-aza-bicyclo[3.2.1]octane-6-carboxylic acid tert-butyl ester was converted to {(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-ethyl-cyclohexyl]-2-oxo-pyrrolidin-3-yl}-carbamic acid benzyl ester. A portion of this material (995 mg, 2.2 mmol) was dissolved in 20 mL of 4:1 CH2Cl2/TFA. The resultant solution was stirred at RT for 3 h and concentrated in vacuo. The residue was dissolved in methylene chloride and concentrated in vacuo; this procedure was repeated twice more to afford benzyl (S)-1-((1S,2R,4R)-4-amino-2-ethylcyclohexyl)-2-oxopyrrolidin-3-ylcarbamate. MS found: (M+H)+=360.2.

後処理

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in methylene chloride
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-80fac905ae8d4916a8aec725d09124ca
出典データセット
uspto-grants-2009_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07482335B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート