HCID 69285697、化合物 → HCID 86596885、化合物

HRID 1455427ノート

反応式

HRID 1455427 の反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][C@@H:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:14][C@H:13]1[CH2:26][S:27]([C:30]([CH3:33])([CH3:32])[CH3:31])(=O)=O)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][C@@H:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:14][C@H:13]1[CH2:26][S:27][C:30]([CH3:33])([CH3:32])[CH3:31]

参加物

4

反応物 1

HCID 69285697HCID 69285697、化合物

生成物 1

HCID 86596885HCID 86596885、化合物収率 104.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate (7.3 g) in MeOH (80 mL) was charged with 10% Pd/C, Degussa (5.0 g). The reaction flask was evacuated and then back-filled with hydrogen; this was repeated three more times. The reaction was stirred under 1 atm of H2 for 3 h and then filtered and concentrated to provide tert-butyl (1R,3R,4S)-4-amino-3-(tert-butylthiomethyl)cyclohexylcarbamate (5.0 g). MS (ES+)=349.3 (M+H)+.

後処理

  1. customThe reaction flask was evacuated
  2. additionback-filled with hydrogen
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-15b553a0e1394d7c91a2492d29e878ba
出典データセット
uspto-grants-2009_01
特許番号
US07482335B2

反応ノート

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