Oxalyl chloride → 3-Methyloxy-2-phenyl-4-quinolinecarbonyl chloride

HRID 1455516ノート

反応式

HRID 1455516 の反応式
[CH3:1][O:2][C:3]1[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:5][C:6]2[C:11]([C:12]=1[C:13](O)=[O:14])=[CH:10][CH:9]=[CH:8][CH:7]=2.C(Cl)(=O)C([Cl:25])=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:5][C:6]2[C:11]([C:12]=1[C:13]([Cl:25])=[O:14])=[CH:10][CH:9]=[CH:8][CH:7]=2

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 6243483-Methoxy-2-phenylquinoline-4-carboxylic acid

生成物 1

HCID 213546903-Methyloxy-2-phenyl-4-quinolinecarbonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-Methyloxy-2-phenylquinoline-4-carboxylic acid (200 mg, 0.72 mmol) [J. Med. Chem. 1999, 42, 1053-1065] was suspended in CH2Cl2 (5 mL) at 0° C. and oxalyl chloride (62 μL, 0.72 mmol) was added with stirring. After stirring at 0° C. for 1 h the cooling bath was removed and the solution allowed to stir at room temperature for 18 h. After this time the solvent was evaporated and the crude acid chloride used in the subsequent reaction without further purification.

後処理

  1. stirringAfter stirring at 0° C. for 1 h the cooling bath
  2. customwas removed
  3. stirringto stir at room temperature for 18 h
  4. customAfter this time the solvent was evaporated
  5. customthe crude acid chloride used in the subsequent reaction without further purification

出典と根拠

ORDレコード
ord-12ece4c756da4312bd7c9d805b68b55c
出典データセット
uspto-grants-2009_01
特許番号
US07482457B2

反応ノート

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