Cyclopropylamine → HCID 57535407、化合物

HRID 1455630ノート

反応式

HRID 1455630 の反応式
CN(C(ON1N=NC2[CH:12]=[CH:13][CH:14]=[N:15]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[Br:25][C:26]1[CH:27]=[C:28]([C:36]([OH:38])=O)[CH:29]=[C:30]2[C:35]=1[N:34]=[CH:33][CH:32]=[CH:31]2.C(N(C(C)C)CC)(C)C.C1(N)CC1>CN(C=O)C.O>[Br:25][C:26]1[CH:27]=[C:28]([C:36]([NH:15][CH:14]2[CH2:12][CH2:13]2)=[O:38])[CH:29]=[C:30]2[C:35]=1[N:34]=[CH:33][CH:32]=[CH:31]2

参加物

7

反応物 4

HCID 69828CyclopropylamineHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 106584338-Bromo-6-quinolinecarboxylic acid

生成物 1

HCID 57535407HCID 57535407、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of HATU (1.2 eq), 8-bromoquinoline-6-carboxylic acid (1 eq), diisopropylethylamine (2.5 eq) and cyclopropylamine (1.1 eq) was stirred at rt for 1 h in DMF (0.2 M). The reaction mixture was diluted with water, stirred for 2 h and extracted with EtOAc. The organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. The residue was crystallized in EtOAc and title product isolated by filtration as a white powder.

後処理

  1. extractionextracted with EtOAc
  2. washThe organic extracts were washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue was crystallized in EtOAc

出典と根拠

ORDレコード
ord-37ddc407970c45cb86fc405e21f1bc56
出典データセット
uspto-grants-2009_01
特許番号
US07482456B2

反応ノート

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