Acetic Acid → 4-Hydroxypiperidine-4-carboxamide
反応式
CC(O)=O.C([N:12]1[CH2:17][CH2:16][C:15]([OH:21])([C:18]([NH2:20])=[O:19])[CH2:14][CH2:13]1)C1C=CC=CC=1>CO.[Pd]>[OH:21][C:15]1([C:18]([NH2:20])=[O:19])[CH2:16][CH2:17][NH:12][CH2:13][CH2:14]1参加物
5
実験手順
Pd/C (150 mg) and HOAc (2 mL) are added to a solution of 1-benzyl-4-hydroxy-piperidine-4-carboxylic acid amide (2 g, 8.5 mmol) in MeOH. The mixture is shaken under H2 (40 psi) for 14 h. The catalyst is removed by filtration and the solvent is removed in vacuo to give the title product. 1H NMR (CD3OD) 2.96(m, 4H), 2.05(m, 2H), 1.49 (m, 2H).
後処理
- customThe catalyst is removed by filtration
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-e75c499357014583b4dd634c321b098d
- 出典データセット
- uspto-grants-2009_01
- 特許番号
- US07482350B2
反応ノート
読み込み中…