1,2,3,6-Tetrahydropyridine → 1-(6-(2-Butynyloxy)pyrimidin-4-yl)-1,2,3,6-tetrahydropyridine
反応式
Cl[C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]#[C:11][CH3:12])[N:5]=[CH:4][N:3]=1.[NH:13]1[CH2:18][CH:17]=[CH:16][CH2:15][CH2:14]1>>[CH2:9]([O:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:13]2[CH2:14][CH:15]=[CH:16][CH2:17][CH2:18]2)[CH:7]=1)[C:10]#[C:11][CH3:12]参加物
3
実験手順
0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.41 g of 1,2,3,6-tetrahydropyridine were mixed and left for 2 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.38 g of 1-(6-(2-butynyloxy)pyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (54)).
出典と根拠
- ORDレコード
- ord-d976352f2ebb4c96abede001169aa40a
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732448B2
反応ノート
読み込み中…