1,2,3,6-Tetrahydropyridine → 1-(4-(2-Pentynyloxy)pyrimidin-6-yl)pyridine
反応式
Cl[C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH:10]=[CH:11][CH2:12][CH3:13])[N:5]=[CH:4][N:3]=1.[NH:14]1[CH2:19][CH:18]=[CH:17][CH2:16][CH2:15]1>>[CH2:9]([O:8][C:6]1[CH:7]=[C:2]([N:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH2:19]2)[N:3]=[CH:4][N:5]=1)[C:10]#[C:11][CH2:12][CH3:13]参加物
3
実験手順
0.3 g of 4-chloro-6-(2-pentenyloxy)pyrimidine and 0.25 g of 1,2,3,6-tetrahydropyridine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.23 g of 1-(4-(2-pentynyloxy)pyrimidin-6-yl)pyridine (hereinafter, referred to as Compound (55)).
出典と根拠
- ORDレコード
- ord-640072bca9d8490abb6427decdcf1384
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732448B2
反応ノート
読み込み中…